Let us introduce you to four young and brilliant scientists who know just about everything but how to cope in the real world. There's Sheldon who is intellectually superior but can't and generally won't interact with the average person. His roommate is Leonard who is equally smart but just wants to be like everyone else -- happy and in love. Howard is an engineer who is constantly thinking of women -- who mostly ignore him. And Raj is a sweet Indian boy who's fear of women makes him mute in their presence. Enter a beautiful new neighbour named Penny who doesn't understand most of what these guys are saying but just might be able to teach them a thing or two about life ... and love.